Research: The extracellular matrix (ECM) is the major component of bone tissue and consists of proteins such as type I collagen and vitronectin.  The adhesion of osteoblasts—the bone forming cells—to the extracellular bone matrix has been shown to be important to processes such as proliferation, differentiation, mineralization, and mechanotransduction.  Consequently, my research concerns the signaling pathways that are activated in the osteoblast due to attachment to these matrix components.  Previous research indicates that osteoblasts and osteoblast precursors respond to different ECM proteins in a unique manner.  We believe that exposing osteoblast precursors to the appropriate ECM can drive these cells to increase their proliferative capacity.  To that end, we are working on designing a three-dimensional scaffold that will maximize proliferative and anabolic responses of osteoblasts to the ECM.

In an aging population, the need for these kinds of artificial scaffolds to facilitate healing of osteoporotic and non-union fractures is great.  Current therapies have many disadvantages including the risk of disease or death to the patient, as well as rejection of the implanted material.  Understanding how osteoblasts respond to their extracellular environment and determining the conditions necessary for the proliferation of osteoblastic precursors in a three-dimensional scaffold will facilitate the development of novel and effective materials that will enhance bone formation and maintenance in vivo.