Booksh Home Page Booksh Group

 

Biomedical Sensing

We're developing portable systems for rapid bedside analysis of target biomarkers.

Shift ImageSPR sensorgram with the fiber optic sensor for determining proteins in buffer(left) and serum(right).

ImageImage

Sensorgrams of imprinted and nonimprinted polymer layers to glucose spiked urine. The sensors are exposed to five cycles of (i)buffer wash, (ii)urine), (i)buffer wash, (iii)NaOH regeneration. Note that the imprinted polymer has the greater signal during exposure to urine from specifically and nonspecifically bound glucose and also during the second buffer wash from specifically bound glucose. At the bottom is the spr shift from a noncoated reference sensor.

Current Research

Our research interest is the development of in-situ chemical sensors for environmental, biomedical, and industrial process monitoring. Specifically, the research group has been concentrating on advancement of fiber optic surface plasmon resonance (SPR) Raman, and fluorescence sensors. In developing these sensors we meld instrumental design with advanced data analysis (Chemometrics) methods to achieve optimal instrumental performance. This research is driven by the realization that many measurement challenges – particularly problems involving analyte selectivity and sensitivity – are not best addressed by solely applying chemistry or physics solutions. These ‘physical’ solutions are often time, labor, and capital expensive. Instead, instrumental selectivity and sensitivity (and robustness) can often be enhanced by incorporating mathematical and statistical analysis of the collected data into the instrumental design.

Department of Chemistry and Biochemistry University of Delaware Newark, DE 19716
Phone: 302-831-2561 | Fax: 302-831-6335 | Lab: 302-831-2625 | Email: kbooksh@udel.edu