Chemistry 652- - - ORGANOMETALLIC CHEMISTRY - - - Spring 2021
Prof. Klaus H. Theopold, 214 Lammot duPont Lab
Tuesdays & Thursdays 2:00 PM - 3:15 PM via Zoom, for now.
Textbook: R. H. Crabtree, The Organometallic Chemistry of the Transition Metals, 7th edition, 2019. (ISBN 978-1-118-13807-6)
The following books provide more information and/or different viewpoints and 'may'(?) be found in the Library.
1. John Hartwig, Organotransition Metal Chemistry - From Bonding to Catalysis , University Science Books, 2010
2. Collman, Hegedus, Norton, Finke; Principles and Applications of Organotransition Metal Chemistry, 2nd edition.
3. G. A. Spessard & G. L. Miessler; Organometallic Chemistry, 2nd edition, 2010.
4. Elschenbroich; Salzer; Organometallics, 2nd or 3rd edition.
5. Kochi; Organometallic Mechanisms and Catalysis.
6. Parshall, Ittel; Homogeneous Catalysis, 2nd edition.
7. Atwood; Inorganic and Organometallic Reaction Mechanisms, 2nd edition.
8. R. B. Jordan; Reaction Mechanisms of Inorganic and Organometallic Systems, 2nd edition, 1998.
9. Huheey; Keiter, and Keiter; Inorganic Chemistry, 4th edition
10. Cotton, Wilkinson; Advanced Inorganic Chemistry, 6th edition.
Midterm (during class, on Thursday, April 1).
A paper - in the form of a research proposal - see below for details (due on April 29).
Reviews of 4 proposals (due on next to last day of class, i.e. May 14).
Comprehensive final (on May 27, 1-3 pm, via Zoom).
Midterm 30 %
Proposal/Reviews 30 %
Problem Sets 10 %
Final 30 %
Total: 100 %
The year is 2028! After completing your Ph.D. at the University of Delaware and a couple of years of postdoctoral research with the famous Prof. Noitall at Ivy U, you have just accepted an assistant professorship at Utopia State University. The chairperson of your department encourages you to secure external funding for your budding research effort. Now what?
Write a short proposal - e.g., to the Petroleum Research Fund of the American Chemical Society, an organization which gives out small "starter grants" - outlining a research project in organometallic(!) chemistry. In no more than 5 single-spaced pages (or the equivalent), this should contain:
- a title and your name
- an abstract (no more than 100 words - i.e., a self-contained summary of your proposal)
- an introduction (background, prior work, significance of your project)
- a description of the research (details of representative experiments to be performed, methods of analysis, anticipated results etc.)
- a bibliography (references to prior work, see J. Am. Chem. Soc. for style).
Your proposal must be submitted electronically by the deadline (as a pdf file entitled 'yourlastname.pdf') to: email@example.com.
Review: Shortly after having submitted your proposal, your prayers to the gods of funding and your teaching schedule are rudely interrupted by the receipt (via e-mail) of several research proposals written by your peers at other institutions of higher learning all across the nation. ACS-PRF is seeking your (anonymous) peer-evaluation of these proposals (by scientific merit, significance, chance of success, technical quality of proposal, etc.). Your comments and ratings will aid the program director in deciding which proposals will be funded this year. Unfortunately, there is not enough money available to fund all proposal (surprise!). Past experience has shown that only ca 30 % of all requests for funding can be accommodated.
Assignment: Write short (~ 200 words) critical reviews of your colleague's proposals and rank them in order of your preference for funding (i.e. assign rankings 1, 2, 3 and 4 - no ties allowed!). Your reviews must justify your rank order, and in the best of all worlds, they should also be helpful to the authors in rewriting their proposal for next year's competition. I will forward your reviews - verbatim - to the proposal authors.
Approximate Class Syllabus:
1 - Introduction: History, 18-electron rule, ligands
2 - Ligands contd, characterization & fluxionality
3 - Reductive Elimination/Oxidative Addition
4 - Migratory Insertion/Elimination
5 - Nucleophilic/Electrophilic attack on coordinated ligands
6 - Metal-carbon Multiple Bonds, Olefin Metathesis, ROMP
7 - CO-chemistry, hydroformylation, Fischer-Tropsch process, etc.
8 - Olefin-chemistry, isomerization, hydrogenation, polymerization
9 - oxidation, high-oxidation state organometallics, O2-activation.
10 - C-H activation
11 - Other small molecule activation (N2, CO2, ...).
12 - Applications in organic synthesis (maybe? guest lectures??)
Overheads shown in class: download a copy of the growing set of PowerPoint slides shown in class Other resources: download a key for problem set #1 download a key for problem set #2 download a key for the midterm exam in 19S download a key for the midterm exam in 20S download a key for the midterm exam in 21S download a key for the 14S final exam download a key for the 15S final exam
Notes generated during online lectures during 21S: Notes for Lecture 1, of February 16 Notes for Lecture 2, of February 18 Notes for Lecture 3, of February 23 Notes for Lecture 4, of February 25 Notes for Lecture 5, of March 2 Notes for Lecture 6, of March 4 Notes for Lecture 7, of March 9 Notes for Lecture 8, of March 11 Notes for Lecture 9, of March 16 Notes for Lecture 10, of March 18 Notes for Lecture 11, of March 23 Notes for Lecture 12, of March 25 Notes for Lecture 13, of April 6 Notes for Lecture 14, of April 8 Notes for Lecture 15, of April 13 Notes for Lecture 16, of April 15 Notes for Lecture 17, of April 20 Notes for Lecture 18, of April 22 Notes for Lecture 19, of April 27 Notes for Lecture 20, of April 29 Notes for Lecture 21, of May 4 Notes for Lecture 22, of May 6 Notes for Lecture 23, of May 11 Notes for Lecture 24, of May 13 Notes for 'the Last Lecture', of May 18
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