The course reader, available at the University of Delaware Bookstore, includes most of the articles below. Background material for most articles and the remaining articles are linked to the journal reference. English translations of are provided in your reader for the two articles originally written in German. Not all of these articles will be read in a given offering of CHEM-342.

1864 Stokes, G. G., On the Reduction and Oxidation of the Colouring Matter of Blood. Proc. Royal Soc. London 13, 355-364. Background material for Stokes (1864).

1886 Zinoffsky, O., Ueber die Grösse des Hämoglobinmolecüls. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 10, 16-34. Background material for Zinoffsky (1886).

1904 Bohr, C., Hasselbalch, K. and Krogh, A., Über einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Saurestoffbindung übt. Skand. Arch. Physiol.16, 401 - 412.

1910 Herrick, J. E., Peculiar Elongated and Sickle-Shaped Red-Blood Corpuscles in a Case of Severe Anemia. Archives of Internal Med. 6, 517-521. Background material for Herrick (1910).

1912 Peters, R. A., Chemical Nature of Specific Oxygen Capacity in Haemoglobin. J. Physiol. 44, 131-149.

1912 Douglas, C. G., Haldane, J. S. and Haldane, J.B.S., The Laws of Combination of Haemoglobin with Carbon Monoxide and Oxygen. J. Physiol. 44, 275-304. Background material for Douglas et al. (1912).

1923 Conant, J. B., An Electrochemical Study of Hemoglobin. J. Biol. Chem. 57, 401-414. Background material for Conant (1923).

1925 Adair, G. S., The Osmotic Pressure of Haemoglobin in the Absence of Salts. Proc.  Royal Soc. London 109A, 292-300

1926 Svedberg, T. and Fåhraeus, R., A New Method for the Determination of the Molecular Weight of the Proteins. J. Am. Chem. Soc. 48, 430-438. Background material for Svedberg and Fåhraeus (1926).

1933 Diggs, L. W., Ahmann, G. F. and Bibb, J., The Incidence and Significance of the Sickle Cell Trait. Annals of Internal Med. 7, 769-778. Background material for Diggs et al. (1933).

1936  Pauling, L. and Coryell, C. D. The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin, and Carbonmonoxyhemoglobin, Proc. Natl. Acad. Sci. USA 22, 210-216.

1946 Shemin, D. and Rittenberg, D., The Life Span of the Human Red Blood Cell, J. Biol. Chem. 166, 627 - 636. Background article by David Shemin, Bioessays 10, (1989).

1949 Pauling, L., Itano, H. A., Singer, S. J. and Wells, I. C., Sickle Cell Anemia, A Molecular Disease. Science 110, 543-548. Background material for Pauling et al. (1949).

1954 Allison, A. C., Protection Afforded by Sickle-Cell Trail Against Subtertian Malarial Infection. Brit. Med. J. 1, 290-294. Background material for Allison (1954). [See also: Allison, Anthony C. (2002) The discovery of resistance to malaria of sickle cell heterozygotes. Biochemistry and Molecular Biology Education 30(5), 279-287.]

1958 Ingram, V. M., Abnormal Human Haemoglobins I. The Comparison of Normal Human and Sickle-Cell Haemoglobins by "Fingerprinting." Biochim. Biophys. Acta 28, 539-545. Background material for Ingram's articles. [See also: Vernon M. Ingram (2004) Sickle-Cell Anemia Hemoglobin: The Molecular Biology of the First "Molecular Disease"—The Crucial Importance of Serendipity, Genetics, 167, 1-7.]

1959 Ingram, V. M., Abnormal Human Haemoglobins III. The Chemical Difference Between Normal and Sickle Cell Haemoglobins. Biochim. Biophys. Acta 36, 402-411. [See also: Ingram, V. M. (1989) A case of sickle-cell anæmia: a commentary by Vernon M. Ingram. Biochem. Biophys. Acta 1000, 147 - 150.]

1960 Perutz, Max F., Rossmann, M.G., Cullis, Ann F., Muirhead, Hilliary, and North, A. C. T. , Structure of Haemoglobin, A Three-dimensional Fourier Synthesis at 5.5 A Resolution Obtained by X-Ray Analysis. Nature 185, 416.

1961 Dintzis, H. M., Assembly of the Peptide Chains of Hemoglobin. Proc. Natl. Acad. Sci. USA 47, 247 - 261. [See also: Dintzis, Howard M. (2006) The wandering pathway to determining N to C synthesis of proteins: Some recollections concerning protein structure and biosynthesis, Biochemistry and Molecular Biology Education 34,(4), 241-246.]

1962 Naughton, M. A. and Dintzis, D. M., Sequential Biosynthesis of the Peptide Chains of HemoglobinProc. Natl. Acad. Sci. USA 48, 1822 - 1830.

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