Kenneth A. Campbell
Assistant Professor
Ph.D., University of Toronto, 1982
kencamp@udel.edu
Phone: Office (302) 831-2924: Fax (302) 831-3645
Office: Room 224M Wolf Hall
Research Interests
How does the neural representation of a stimulus event change when the
event acquires biological significance to the animal? Work in my laboratory
uses a combination of neurophysiological, pharmacological, and behavioral
approaches to examine mechanisms of sensory processing in the limbic system.
Specifically, we use the evoked potential technique to assess processing
of auditory events in limbic sites such as the hippocampus, amygdala and
limbic cortex in freely-moving rats. We are interested in the effects on
limbic auditory evoked potentials of manipulations of arousal, motivation
and learning. We are also studying the synaptic pharmacology and plasticity
of the pathways that generate and modulate limbic evoked potentials. Health-related
applications of this work have involved the use of evoked potentials to
investigate the neural basis of cognitive sensory processing deficits that
accompany drug abuse, and aging: in the latter case, we have also used
evoked potentials to assess the therapeutic potential of putative cognition-enhancing
compounds.
Representative Publications
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Campbell, K.A., Kalmbacher, C.E., Specht, C.D., & Gregg, T.R. (1995)
Dependence of rat vertex auditory evoked potentials on central muscarinic
receptor activation. Brain Research, 702, 110-116.
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Campbell, K.A. (1990) Plasticity in the propagation of hippocampal stimulation-induced
activity: A [14C]-2-Deoxyglucose mapping study. Brain Research,
520, 199-207.
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Campbell, K.A., Foster, T.C., Hampson, R.E. & Deadwyler, S.A. (1986)
Delta9tetra-hydrocannabinol differentially affects sensory evoked
potentials in the rat dentate gyrus. Journal of Pharmacology & Experimental
Therapeutics, 239, 936-940.
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Campbell, K.A., Foster, T.C., Hampson, R.E. & Deadwyler, S.A. (1986)
Effects of delta9tetrahydrocannabinol on sensory evoked discharges
of granule cells in the dentate gyrus of behaving rats. Journal of Pharmacology
& Experimental Therapeutics, 239, 941-945.
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