CHEM-642 Biochemistry
Tentative Schedule  -  Spring 2000

Meeting Time and Place: Section 10 meets 9:30 to 10:45 AM Tuesdays and Thursdays in 219 Gore Hall. Section 11 meets 7 to 8:15 PM Tuesdays and Thursdays in 210 Brown Laboratory. Because morning and evening lectures will be presented by the same professor and because there will be common hourly and final examinations for both sections, students may attend either or both lectures. The first half of the course will be taught by Prof. Hal White and the second half by Prof. Junghuei Chen. Text chapters and sections in parentheses refer to Garrett and Grisham's, BiochemistryCopies of the overheads used by Dr. Chen are on reserve in the Chemistry Library in Brown Laboratory.
 

Tuesdays 9:30-10:45 AM & 7:00-8:15 PM Thursdays 9:30-10:45 AM & 7:00-8:15 PM
February 8
Introduction and Review of Metabolic Principles 
       (Chapter 18.1-18.3)
February 10

Glycogen Synthesis and Degradation 
       (Chapter 23.3 - 23.5) Pentose Phosphate Pathway  (Chapter 23.6)
 

February 15
Oxidation of Odd-Chain Length and
       Unsaturated Fatty Acids, Lipid Structure 
       (Chapter 8)
Biosynthesis of Lipids (Chapter 25)
Problem Set 1 due
February 17
Ketone Body Formation (Chapter 24.3-24.6)
Biosynthesis of Lipids cont. (Chapter 25)
Membranes & Selected Topics 
       (Chapters 9 & 10)
February 22
Lipid Metabolism and Membranes cont.
        (Chapters 9, 10, and 25)
Problem Set 2 due
February 24
Lipid Metabolism and Membranes cont.
       (Chapters 9, 10, & 25)
February 29
Nitrogen Acquisition and Excretion
        (Chapter 26)
Problem Set 3 due
March 2 
Amino Acid Metabolism  (Chapter 26)
March 7
Amino Acid Metabolism cont. (Chapter 26)
Problem Set 4 due
March 9
Amino Acid Metabolism cont. (Chapter 26)
March 14
Integration of Metabolism and Review for 
        Midterm Examination
March 16
Overview of Nucleotide Metabolism 
         (Chapters 11 & 27)
(Midterm Examination Saturday March 18, 
10 AM - noon in 101 Brown Laboratory.)
March 21
Introduction to Molecular Biology 
March 23
No class in lieu of the out-of-class midterm 
        examination on March 18
March 28    SPRING BREAK March 30    SPRING BREAK
April 4
Structure and Function of DNA, History of the experiments showing DNA is the Genetic material.
April 6
Properties of DNA, Secondary structure, Supercoiling and linking numbers
April 11
Topoisomerases, DNA packing, Chromosome structure.
April 13
DNA replication in prokaryotes and eukaryotes, Central Dogma
April 18
Primosomes and Replisomes, DNA polymersaes, Mechanism of replication
April 20
Eukaryotic replication, "Reverse transcriptase," Mutation and DNA repair



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Last updated 21 April 2000 by Hal White.
Copyright 2000, Harold B. White, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716