Problem-Based Learning (PBL) Articles
in Biochemical Education (1992-2000) &
Biochemistry and Molecular Biology Education (2000-2004)

In 1993, Biochemical Education initiated a regular Features Section on problem-based learning edited by C. A. Smith. Although most of the early articles deal with medical education, many problems and comments apply to biochemical education in general. A list of those and related articles organized by category follow. This list undoubtedly contains some omissions. I intend to update this list from time to time as PBL articles are published in Biochemistry and Molecular Biology Education (BAMBED).

Last Up-dated 25 March 2004
Editorial Commentaries PBL Critiques PBL Problems
PBL Methods and Practice PBL Curricula Problem-Solving Tests
Reviews of PBL Books and Meetings PBL Courses

Editorial Commentaries:

E. J. Wood, "Weighed down by information" Biochemical Education 20(1), 1 (1992).

E. J. Wood, "Problem-based learning" Biochemical Education 21(4), 169 (1993).

C. A. Smith, (commentary initiating the PBL Features Section) Biochemical Education 21(1), 32 (1993).

C. A. Smith, (commentary) Biochemical Education 21(4), 200 (1993).

C. A. Smith, (commentary) Biochemical Education 22(1), 36 (1994).

C. A. Smith, (commentary on questioning) Biochemical Education 26(4), 292-293 (1998).

C. A. Smith, "PBL and Research Projects" Biochemical Education 27(1), 14 (1999).

C. A. Smith, "Self-assessment in problem-based learning" Biochemical Education 27(2), 86 (1999).

C. A. Smith, "Student learning" Biochemical Education 27(3), 155 (1999).

C. A. Smith, "Enzymes, Control, Metabolism and Regulation" Biochemical Education 27(4), 214 (1999).

C. A. Smith, "PBL and veterinary medicine" Biochemical Education 28(1), 29 (2000).

C. A. Smith, "Enzyme Problems" Biochemical Education 28(3), 143 (2000).

H. B. White, "Experimenting with problem-based learning" Biochemistry and Molecular Biology Education 28(4), 211 (2000).

H. B. White, "Case method and problem based learning" Biochemistry and Molecular Biology Education 28(5), 265-266 (2000).

H. B. White, "Why teach enzyme kinetics" Biochemistry and Molecular Biology Education 28(6), 330-331 (2000).

H. B. White, "PBL curricula versus PBL courses" Biochemistry and Molecular Biology Education 29(1), 24-25 (2001).

H. B. White, "What makes PBL tutors different?" Biochemistry and Molecular Biology Education 29(2), 79 (2001).

H. B. White, "Simple analogies for teachers and students new to PBL" Biochemistry and Molecular Biology Education 29(3), 115 (2001).

C. A. Smith & H. B. White, "The problem-based learning page of Biochemical Education 1993-2000" Biochemistry and Molecular Biology Education 29(4), 153-154 (2001).

H. B. White, "PBL, faculty development, and institutional change" Biochemistry and Molecular Biology Education 29(5), 204-205 (2001).

H. B. White, "Problem-based learning and the power of stories" Biochemistry and Molecular Biology Education 29(6), 255-256 (2001).

G. R. Parslow, "Better assessment to improve teaching and learning" Biochemistry and Molecular Biology Education 29(6), 262-263 (2001).

H. B. White, "Problem-based Testing" Biochemistry and Molecular Biology Education 30(1), 56 (2002).

H. B. White, "Problem-based Learning and disciplinary boundaries" Biochemistry and Molecular Biology Education 30(2), 120 (2002).

H. B. White, "Writing and Individual accountability in problem-based learning" Biochemistry and Molecular Biology Education 30(3), 196 (2002).

H. B. White, "Looking for good Problem-based Learning Problems" Biochemistry and Molecular Biology Education 30(4), 248 (2002).

H. B. White, "Classic articles as problem-based learning problems" Biochemistry and Molecular Biology Education 30(5), 313 - 314 (2002).

H. B. White, "Commentary: The promise of problem-based learning" Biochemistry and Molecular Biology Education 30(6), 419 (2002).

H. B. White, "Commentary: Preparing Group facilitators for problem-based learning" Biochemistry and Molecular Biology Education 31(2), 131 (2003).

H. B. White, "Commentary: Making problem-based medical education work" Biochemistry and Molecular Biology Education 31(3), 188-189 (2003).

H. B. White,  "Wrap-up assignments for problem-based learning problems" Biochemistry and Molecular Biology Education 31(4), 260-261 (2003).

H. B. White, "Commentary: Problem-based Learning and Becoming a Physician" Biochemistry and Molecular Biology Education 31(5), 337 (2003).

H. B. White, "Commentary: Hiring Researchers Who Teach" Biochemistry and Molecular Biology Education 31(6), 422-423 (2003).

H. B. White, "Problem-based Learning and Undergraduate Research" Biochemistry and Molecular Biology Education 32(1), 49 (2004).

PBL Methods and Practice:

Christopher A. Smith, Susan C. Powell, and Edward J. Wood, "Problem-based learning and problem-solving skills" Biochemical Education 23(3), 149-152 (1995).

L. Henderson, "A first period exercise in biochemistry: a pre-assessment case study" Biochemical Education 26(2), 141 - 142 (1998).

Bayardo B. Torres, "Learning by posing questions" Biochemical Education 26(4), 294-296 (1998).

Francesco Ranaldi, Poalo Vanni, Eugenio Giachetti, "What students know about the determination of enzyme kinetic parameters" Biochemical Education 27(2), 87-91 (1999).

Srinivasan, "The role of mutants in metabolic regulation" Biochemical Education 27(4), 215 - 216 (1999).

D. B. Fialho, J. B. T. Rocha, and C. F. Mello, "An introductory student-centred class to teach concepts related to spectrophotometry in a biochemistry practical laboratory course" Biochemical Education 27(4), 217 - 220 (1999).

P. K. Rangachari, "The TRIPSE: A process-oriented evaluation for problem-based learning in basic sciences" Biochemistry and Molecular Biology Education 30(1), 57-60 (2002).

T. Platt, E. Barber, A. Yoshinaka, and V. Roth,"An innovative selection and training program for problem-based learning (PBL) workshop leaders in biochemistry" Biochemistry and Molecular Biology Education 31(2) 132-136 (2003).

S. A. Azer, "Assessment in a Problem-based Learning Course: Twelve Tips for Constructing Multiple Choice Questions That Test Students' Cognitive Skills" Biochemistry and Molecular Biology Education 31(6), 428-434 (2003). 

Problem-solving Tests

József Szeberényi, "Problem-solving tests for problem-based learning-Introduction" Biochemistry and Molecular Biology Education 30(1), 61 (2002).

József Szeberényi, "The mechanism of action of anthrax toxin lethal factor" Biochemistry and Molecular Biology Education 30(1), 62-63 (2002).

József Szeberényi, "The Molecular pathomechanism of Tay-Sachs Disease" Biochemistry and Molecular Biology Education 30(3), 197-199 (2002).

József Szeberényi, "Restriction Mapping" Biochemistry and Molecular Biology Education 30(4) 258-259 (2002).

József Szeberényi, "Insulin Signaling" Biochemistry and Molecular Biology Education 30(5) 322-323 (2002).

József Szeberényi, "Lactose operon mutants" Biochemistry and Molecular Biology Education 30(6) 420-421 (2002).

József Szeberényi, "Role of a chaparone in protein synthesis" Biochemistry and Molecular Biology Education 31(2) 137-138 (2003).

József Szeberényi, "Glucose Transport in Liposomes" Biochemistry and Molecular Biology Education 31(3) 195-196 (2003).

József Szeberényi, "In vitro Analysis of DNA Polymerases" Biochemistry and Molecular Biology Education 31(4) 262-263 (2003).

József Szeberényi, "The Ames Test" Biochemistry and Molecular Biology Education 31(5) 344-345 (2003).

József Szeberényi, "The Regulation of the Function of the Tuimor Suppressor Protein p53" Biochemistry and Molecular Biology Education 31(6) 435-436 (2003).

József Szeberényi, "The Expression of Ovomucoid Gene" Biochemistry and Molecular Biology Education 32(1) 50-51 (2004).

PBL Critiques and Reflections:

Peter N. Campbell, "Some thoughts on problem-based learning" Biochemical Education 23(4), 202 - 204 (1995).

Linda C. Hodges, "A Professor's Pathway through Problem-based Learning" Biochemistry and Molecular Biology Education 30(4), 255 - 257 (2002).

Robert H. Glew, "The Problem with Problem-based Learning: Promises not Kept" Biochemistry and Molecular Biology Education 31(1), 52-56 (2003). 

G. R. Parslow,  "Websites of note, Problem-based learning at the University of Delaware" Biochemistry and Molecular Biology Education 31(2), 153 (2003). 

D. A. Goodenough,  "Problem-based Learning, Resources, and Science in Medical Education" Biochemistry and Molecular Biology Education 31(3), 190-191 (2003). 

P. K. Rangachari,  "Poised between the Pedantic and the Puerile: Physicians-to-be in a Problem-based Program" Biochemistry and Molecular Biology Education 31(3), 192-194 (2003). 

C. F. Herreid,  "Response to: The Problem with Problem-based Medical Education: Promises not Kept by R. H. Glew" Biochemistry and Molecular Biology Education 31(4), 253-254 (2003). 

H. Barrows,  "Response to: The Problem with Problem-based Medical Education: Promises not Kept by R. H. Glew" Biochemistry and Molecular Biology Education 31(4), 255-256 (2003).

I. E. Hughes and E. J. Wood,  "Response to: The Problem with Problem-based Medical Education: Promises not Kept by R. H. Glew" Biochemistry and Molecular Biology Education 31(4), 257-259 (2003).

M. Savin-Baden,  "Disciplinary Differences or Modes of Curriculum Practice?: Who Promised to Deliver What in Problem-based learning?" Biochemistry and Molecular Biology Education 31(5), 338-343 (2003).

Robert H. Glew, "Response to Commentaries on 'The Problem with Problem-based Learnoing' in Biochemistry and Molecular Biology Education" Biochemistry and Molecular Biology Education 31(6), 424-427 (2003). 

PBL Curricula:

Toshihiro Sugiyama, Fumihide Isohashi, Taneaki Higashi, Hiroyuki, Kagamiyama, Kunio Tagawa, and Naoyuki Taniguchi, "Introduction and implementation of problem-solving lectures for instruction in medical biochemistry at Osaka University Medical School in Japan" Biochemical Education 19(2), 58 - 63 (1991).

Alvin Newman, "The new Toronto medical curriculum" Biochemical Education 21(4), 170-179 (1993).

Christopher W. Helleiner and Louis A. V. Fernandez, "Problem-based learning of biochemistry in a medical curriculum" Biochemical Education 21(3), 143 -146 (1993).

R. D. Cohen, "How much biochemistry should a medical student be taught? - the viewpoint of the General Medical Council" Biochemical Education 24(2), 80 -82 (1995).

E. J. Wood, "How much biochemistry should a good doctor know? A biochemist's viewpoint" Biochemical Education 24(2), 82 - 85 (1995).

Reg Dennick, "How much biochemistry should a good doctor know? An educationist's perspective" Biochemical Education 24(2), 85 -88 (1995).

T. M. Harrison, "A new curriculum at Leicester" Biochemical Education 24(2), 88 -90 (1995).

Keith Burdett, "The Manchester medical programme" Biochemical Education 24(2), 90 - 91 (1995).

John Smith, "The new medical curriculum at Liverpool University" Biochemical Education 24(2), 91 - 92 (1995).

Barbara Moreland, "Current position of UK medical schools with respect to curriculum changes" Biochemical Education 24(2), 92 - 93 (1995).

Charles L. Harris, Gül Güner, James Arbogast, Lisa Salati, James M. Shumway, John Connors, and Diana Beattie, "Integrated Problem Based Learning for First Year Medical Student: Does it Teach Biochemical Principles?" Biochemical Education 25(3), 146 - 150 (1997).

Sheela Surlekar, "Teaching biochemistry in a 'Guided Discovery Curriculum'" Biochemical Education 26(3), 218-222 (1998).

Anila Jaleel, M. Ataur Rahman, and Nighat Huda, "Problem-based learning in biochemistry at Ziauddin Medical University, Karachi, Pakistan" Biochemistry and Molecular Biology Education 29(2), 80-84 (2001)
 

PBL Courses:

Harold B. White, III, "Introduction to biochemistry: a different approach" Biochemical Education 20(1) 22-23 (1992).

A. E. Gubareva, "Teaching by posing questions" Biochemical Education 20(4), 226 -227 (1992).

Norman R. Cohen, "Problem-based learning and the distance learner" Biochemical Education 22(3), 126 -131 (1994).

Harold B. White, III, "Addressing content in problem-based learning course: the learning issue matrix" Biochemical Education 24(1), 41 - 45 (1996).

Les Jervis and Paul Morris, "Environmental biochemistry - a problem-based approach" Biochemical Education 24(4), 215 -221 (1996).

József Szeberényi, "Problem-solving in molecular biology" Biochemical Education 24(4), 222 - 225 (1996).

Peter McCrorie and Mark Carroll, "The assessment of 'Metabolism' taught in an integrated systems-based medical curriculum" Biochemical Education 26(3), 214 217 (1998).

Vivanna A. Rivarola, and Mirta B. García, "Problem-based learning in veterinary medicine: protein metabolism" Biochemical Education 28(1), 30 - 31 (2000).

Elizabeth Johnson, Susanna Herd, Kathy Andrewartha, Steve Jones, and Susan Malcolm, "Introducing problem-based learning into a traditional lecture course" Biochemistry and Molecular Biology  Education 30(2), 121-124 (2002).

PBL Problems:

Maureen M. Dawson and Ian Graham, "Data handling problems in immunochemistry" Biochemical Education 21(1), 33 - 36 (1993).

John M. Walker, "Proteins - calculations and interpretative questions" Biochemical Education 21(2), 89 -92 (1993).

E. James Milner-White, "Some problem questions on interactions between molecules of biological importance" Biochemical Education 21(2), 92 - 93 (1993).

Kenneth E. Backen and Christopher A. Smith, "Problem-solving questions in Examinations" Biochemical Education 21(4), 200-204 (1993).

Harold B. White, III, "Research literature as a source of problems" Biochemical Education 21(4), 205 - 207 (1993).

Paul S. Agutter, "Intracellular solute movements: a problem-oriented lecture for final year undergraduates" Biochemical Education 22(1), 32 - 35 (1994).

Paul S. Agutter, Kate S. Morss, and Anita M. Tunstall, "Problems in biological chemistry for students of biological sciences: Molarity, pH and buffering" Biochemical Education 22(1) 36- 39 (1994).

E. J. Wood, "The problems of problem-based learning" Biochemical Education 22(2), 78 - 82 (1994).

Peter C. Gowland, "Determination of the molecular size of a plastid following restriction endonuclease digestion" Biochemical Education 22(2), 95 - 96 (1994).

Christopher J. Cramer, "Problems and questions in the molecular modeling of biomolecules" Biochemical Education 22(3), 140 - 143 (1994)

Malcolm N. Jones, "Protein stability: a problem in physical biochemistry" Biochemical Education 22(4) 196 - 198 (1994)

V. H. Mulimani, "Teaching metabolic pathways to understand its regulation" Biochemical Education 23(1), 32 - 34 (1995).

Frédéric Cadet, "A spectacular demonstration of the disaccharide link" Biochemical Education 23(2), 86 - 89 (1995).

Giuseppe Inesi, "Problem-based understanding of active transport" Biochemical Education 23(3), 152 - 154 (1995).

Simon G. Welch and Mark Carroll, "A new erythrocyte enzyme polymorphism?" Biochemical Education 23(4), 204 - 207 (1995).

Frédéric Cadet, "Theoretical support for the existence of a sedoheptulose-1,7-bisphosphate involved in chloroplast photosynthesis pathway" Biochemical Education 24(1), 36 - 40 (1996).

Christine Robert and Frédéric Cadet, "Thermal denaturation of an enzyme - choice of a model" Biochemical Education 24(3), 154 - 157 (1996).

Christine Robert and Frédéric Cadet, "The inhibition of studies on Polyphenoloxidase by cysteine" Biochemical Education 24(3), 157 - 159 (1996).

Viviana A. Rivarola, Jorge R. Bergesse, Mirta B. Garcia, and Adriana C. Fernandez, "A problem-based learning approach to a biological chemistry laboratory class for students in veterinary science" Biochemical Education 25(1), 22 - 23 (1997).

Pascal Baret and Frédéric Cadet, "Regulation of photosynthetic enzymes via redox systems" Biochemical Education 25(1), 24 - 26 (1997).

Chris G. Whiteley, "Enzyme kinetics: partial and complete competitive inhibition" Biochemical Education 25(3), 144-146 (1997).

M. M. Dawson, P. Kumar and C. A. Smith, "Data handling problems in cell biology" Biochemical Education 25(4), 221-223 (1997).

Alan Hinchliffe, "Modelling molecular structures" Biochemical Education 26(1), 35 - 39 (1998)

Chris G. Whiteley, "Enzyme kinetics: partial and complete non-competitive inhibition" Biochemical Education 27(1), 15-18 (1999).

Stéphanie Ricquebourg, Maya Cesari, and Frédéric Cadet, "Biochemical phenomena associated with the process of leaf senescence in plants: a student problem" Biochemical Education 27(3), 156 - 158 (1999).

Chris G. Whiteley, "Enzyme kinetics: partial and complete uncompetitive inhibition" Biochemical Education 28(3), 144-147 (2000).

Susannah Gal and Jessie W. Klein, "A case for college molecular biology clasess: a right to her genes" Biochemistry and Molecular Biology Education 28(5), 267 - 271 (2000).

Diego M. Bustos and Alberto A. Iglesias, "The kinetic properties of liver glucokinase and its function in glucose physiology as a model for the comprehensive study of enzymes' kinetic parameters and reversible inhibitors" Biochemistry and Molecular Biology Education 28(6), 332 - 337 (2000).

Bernard Offmann and Frédéric Cadet, "Redox-active Disulfides in a Plant Light Switch: A PBL Problem" Biochemistry and Molecular Biology Education 30(4), 249 - 254 (2002).

H. B. White, "Plants versus animals in the dining hall: A problem-based learning problem" Biochemistry and Molecular Biology Education 30(5), 315 - 321 (2002).

Reviews of Books with a PBL Perspective:

F. Vella, review of, The Logic of Biochemical Sequencing by D. S. Blackman CRC Press, Biochemical Education 22(2),108 - 109 (1994).

F. Vella, review of, Nutritional Biochemistry by T. Brody, Academic Press, Biochemical Education 22(3), 171 (1994).

F. Vella, review of, Basic Medical Biochemistry, a Clinical Approach by D. B. Marks, A. D. Marks, and C. M. Smith, Williams and Wilkins, Biochemical Education 24(2), 238 - 239 (1996).

F. Vella, review of, The Biochemistry Student Companion by A. J. Scism, Prentice Hall, Biochemical Education 25(2), 94 (1997).

E. J. Wood, review of, Biochemistry, a Case-Oriented Approach. Sixth Edition by R. Montgomery, T. W. Conway, A. A. Spector and D. Chappell, Mosby, Biochemical Education 25(2), 95 (1997).

F. Vella, review of, Clinical Studies in Medical Biochemistry (Second Edition) edited by R. H. Glew and Y. Ninomiya, Oxford University Press, Biochemical Education 26(1) 96-97 (1998).

E. J. Wood, review of, The Challenge of Problem-based Learning (Second Edition),edited by D. Boud and G. E. Feletti, Gogan Page, Biochemical Education 26(2), 187 (1998).

E. J. Wood, review of, Cases in Biochemistry, by Kathleen Cornely, Wiley, Biochemistry and Molecular Biology Education 29 (6) 273-274 (2001)

Kathleen Cornely, review of conference, PBL2002: A Pathway to Better Learning, Biochemistry and Molecular Biology Education 30(6) 422-423 (2002)


Prepared by Hal White, University of Delaware, for the ASBMB/IUBMB Satellite Meeting, San Francisco, August 23, 1997.
Biochemistry and Molecular Biology Education web-site
Updated 26 March 2004