Ordered
alphabetically by student's last name
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| Brady, A | Cheong | Desai | |||||
| Brady, M |
Greenwood |
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| Decker | Grindel |
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Adam Brady1, Deni S. Galileo1, Balaji Panchapakesan2 Departments of 1Biological Sciences and 2Electrical Engineering |
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Jessica Bruton, Sarah Woody, Minghai Shao, Deni Galileo, Patricia A. Martin-DeLeon Department of Biological Sciences |
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INBRE.
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| Colleen M. Cheong and Ulhas P. Naik Department of Biological Sciences |
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CD44 and Posterior Capsular Opacification (PCO) <>Vivek D. Desai, Yan Wang, and Melinda K. Duncan, Department of Biological Sciences Posterior capsular
opacification (PCO) arises
from epithelial-mesenchymal transition (EMT) of lens epithelial cells
remaining
behind following cataract surgery. In cancer systems, CD44, a receptor
for
hyaluronan, mediates changes in cellular proliferation and migration
that
eventually result in EMT, although CD44 function in EMT has not been
previously
studied in the lens. In the normal adult mouse lens, we found CD44
protein and
mRNA only in the lens fiber cells with no detectable expression in the
lens
epithelium. Following cataract surgery in mice, CD44 expression is
highly
up-regulated in the remaining lens epithelial cells 12 hours following
the
surgery and this expression remains elevated during the EMT process.
CD44 null
mice did not exhibit any qualitative differences in the timing or
extent of
expression of the EMT marker, -SMA, as compared to wild-type (WT)
suggesting
that CD44 is not essential for TGFβ mediated EMT. However, the kinetics
of CD44
up-regulation in the mouse cataract surgery model suggests that it is
one of
the earliest molecular markers ever described for lens response to
injury and
may serve as a good model to understand the early events in the lens
epithelial
response to injury and the sensitization of these cells to later TGFβ
mediated
EMT. Notably, CD44 expression is known to be up-regulated in response
to
hepatocyte growth factor (HGF) mediated signaling and HGF has been
reported to
be a potent mitogen for lens epithelial cells Future work will
investigate the
hypothesis that HGF mediated signaling up-regulates in the lens in
response to
injury leading to up-regulation of CD44 expression and sensitization of
lens
cells to TGFβ mediated EMT. Supported by Beckman
and Barry
M. Goldwater Scholarships.
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Esophageal
resections: An institutional experience The
primary objective of this research study is to evaluate the charts of
149
esophageal cancer patients to create a data base including the
patients’
relevant information to attempt to find a correlation between
variables. After
finding numerous scientific journals that stated a cause and effect
relationship between Barrett’s Esophagus and adenocarcinoma of the
esophagus,
other journals that were found stated no correlation between the two.
This
brought about the question of whether or not this is a connection
present in |
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Brian Grindel, Mary
C. Farach-Carson, and Joseph Bennett
University |
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| Biology
Abstracts for students with last names
starting with L-Z. |