MAHENDRA KUMAR JAIN
RECENT PUBLICATIONS

Books and reviews (*)

  1. M. K. Jain and M. H. Gelb (1991). Methods in Enzymology 197: 112-125. Phospholipase A2 catalyzed hydrolysis of vesicles: uses of interfacial catalysis in the scooting mode.
  2. F. Ramirez and M. K. Jain, Proteins 9, 229-239 (1991). Phospholipase A2 at the bilayer interface. (*)
  3. R. Apitz and M. K. Jain, in Garlic and Health, Nutrition International (1991). A review on the antithrombotic and other biological actions of ajoene, a well-characterized compound derived from garlic. (*)
  4. M. H. Gelb, O. Berg, M. K. Jain (1991). Current Biology 1, 836-843. Quantitative and structural analysis of inhibitors of phospholipase A2. (*)
  5. O. G. Berg, B.-Z. Yu, J. Rogers, M. K. Jain (1991). Biochemistry, 30:7283-7297. Interfacial catalysis by phospholipase A2: Determination of the interfacial kinetic rate constants.
  6. M. K. Jain, G. N. Ranadive, J. Rogers, B.-Z. Yu, O. G. Berg (1991). Biochemistry 30:7306-7317. Interfacial catalysis by phospholipase A2: Dissociation constants for calcium, substrate, products, and competitive inhibitors.
  7. F. Ghomashchi, B.-Z. Yu, O. G. Berg, M. K. Jain, M. H. Gelb (1991). Biochemistry 30:7318-7329. Interfacial catalysis by phospholipase A2: Substrate specificity in vesicles.
  8. M. K. Jain, G. N. Ranadive, B.-Z. Yu, H. M. Verheij (1991). Biochemistry 30:7330-7340. Interfacial catalysis by phospholipase A2: Monomeric enzyme is fully catalytically active at the bilayer interface.
  9. M. K. Jain, J. Rogers, O. Berg, M. H. Gelb (1991). Biochemistry 30:7340-7348. Interfacial catalysis by phospholipase A2: Activation by substrate replenishment.
  10. F. Ghomashchi, B.-Z. Yu, E. D. Mihelich, M. K. Jain, M. G. Gelb (1991). Biochemistry 30:9559-9569. Kinetic characterization of phospholipase A2 modified by manoalog.
  11. M. K. Jain, W. Tao, J. Rogers, C. Arenson, H. Eibl, and B.-Z. Yu (1991). Biochemistry 30:10256-10268. Active-site directed specific competitive inhibitors of phospholipase A2: Novel transition state analogous.
  12. R. Apitz, M. K. Jain, F. Bartoli, E. Ledezma, M. C. Ruiz, and R. Salas (1991). Biochim. Biophys. Acta 1094:269-280. Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with antiplatelet compound ajoene.
  13. M. K. Jain, B.-Z. Yu, M. H. Gelb, Berg, O. G. (1992). Mediators of Inflammation 1, 85-100. Assay of phospholipase A2 and their inhibitors by kinetic analysis in the scooting mode. (*)
  14. M. K. Jain, Membrane: State of the Art, pp. 263-272 (1992). Adenine Press. Eds. Bruce P. Gaber and K.R.K. Easwaran. Interfacial kinetic parameters for catalysis by phospholipase A2. (*)
  15. M. H. Gelb, M. K. Jain, O. G. Berg (1992). Bioorganic & Medicinal Chemistry Letters 2:1335-1342. Interfacial enzymology of phospholipase A2. (*)
  16. F. Ghomashchi, S. Schuttel, M. K. Jain, M. H. Gelb (1992). Biochemistry 31:3814-3824. Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: Divalent metal-dependent trapping of enzyme on product-containing vesicles.
  17. J. Rogers, B.-Z. Yu, M. K. Jain (1992). Biochemistry 31:6056-6062. Basis for the anomalous effect of competitive inhibitors on the kinetics of hydrolysis of short chain phosphatidylcholines by phospholipase A2.
  18. C. M. Dupureur, B.-Z. Yu, M. K. Jain, J. P. Noel, T. Deng, Y. Li, I. L. Byeon, M. D. Tsai (1992). Biochemistry 31:6402-6413. Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73.
  19. M. K. Jain, B.-Z. Yu, J. Rogers, M. H. Gelb, M. D. Tsai, E. K. Hendrickson, S. Hendrickson (1992). Biochemistry 31:7841-7847. Interfacial catalysis by phospholipase A2: The rate-limiting step for enzymatic turnover.
  20. C. M. Dupureur, B.-Z. Yu, J. A. Mamone, M. K. Jain, M. D. Tsai (1992). Biochemistry 31:10576-10583. Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich.
  21. M. K. Jain, F. Ghomashchi, B.-Z. Yu, T. Bayburt, D. Murphy, D. Houck, J. Brownell, J. C. Reid, J. E. Solwiej, S. M. Wong, U. Mocek, R. Jarrell, M. Sasser, M. H. Gelb (1992). J. Med. Chem. 35:3584-3586. Fatty acid amides: Scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2.
  22. A. B. Fisher, C. Dodia, A. Chander, M. K. Jain (1992). Biochemical Journal 288:407-411. A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung.
  23. S. V. Serves, G. M. Tsivgoulis, D. N. Sotiropoulos, P. V. Ioannou, M. K. Jain (1992). Phosphorus, Sulfur and Silicon 71:99-105. Synthesis of (R)- and (S)-1,2-diacyloxypropyl-3-arsonic acids: Optically active arsonolipids.
  24. A. B. Al-Mehdi, C. Dodia, M. K. Jain, A. B. Fisher (1993). Biochim. Biophys. Acta 1167:56-62. A phospholipase A2 inhibitor decreases generation of thiobarbituric acid reactive substance during lung ischemia-reperfusion.
  25. T. Bayburt, B.-Z. Yu, H. Lin, J. Browning, M. K. Jain, M. H. Gelb, (1993). Biochemistry 32:573-582. Human nonpancreatic secreted phospholipase A2: Interfacial parameters, substrate specificities, and competitive inhibitors.
  26. S. V. Serves, D. N. Sotiropoulos, P. V. Ioannou, M. K. Jain (1993). Phosphorus, Sulfur and Silicon 81:181-190. One pot synthesis of arsonolipids via thioarsenite precursors.
  27. B.-Z. Yu, O. G. Berg, M. K. Jain (1993). Biochemistry 32:6485-6492. The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2.
  28. M. K. Jain, J. Rogers, H. S. Hendrickson, O. G. Berg (1993). Biochemistry 32:8360-8367. The chemical step is not rate-limiting during the hydrolysis by phospholipase A2 of mixed micelles of phospholipid and detergent.
  29. M. K. Jain and B. P. Maliwal (1993). Biochemistry 32:11838-11846. Spectroscopic properties of the states of pig pancreatic phospholipase A2 at interfaces and their possible molecular origin.
  30. M. K. Jain, B.-Z. Yu, O. G. Berg (1993). Biochemistry 32:11319-11329. Relationship of interfacial equilibria to interfacial activation of phospholipase A2.
  31. J. M. Rogers and M. K. Jain (1993). The Quarterly Review of Biology 68:387-397. Inference and successful behavior. (*)
  32. M. K. Jain and R. Apitz-Castro (1993). Current Science 65:148-156. Garlic: A product of spilled ambrosia. (*)
  33. G. C. Upreti and M. K. Jain (1993). Bioscience Reports 13:233-243. Interaction of poridesmin, a mycotoxin from Pithomyces chartarum, with lipid bilayers.
  34. M. K. Jain and R. Apitz, in Spices, Herbs and Edible Fungi, Developments in Food Sci., Vol. 34, 309-327, G. Charalambous (ed.), Elsevier (1994). Garlic: A matter for heart. (*)
  35. J. J. Volwerk, E. Filthuth, O. H. Griffith, M. K. Jain (1994). Biochemistry 33: 3464-3474. Phosphoinositol-specific phospholipase C from Bacillus cereus at the lipid-water interface: Interfacial binding, catalysis and activation.
  36. B. P. Maliwal, B.-Z. Yu, H. Szacinski, T. Squier, J. van Binsbergen, A. J. Slotboom, M. K. Jain (1994). Biochemistry 33: 4509-4516. Functional significance of the conformational dynamics of the N-terminus segment of secreted phospholipase A2 at the interface.
  37. M. K. Jain, C. D. Krause, J. T. Buckley, T. Bayburt, M. G. Gelb (1994). Biochemistry 33: 5011-5020. Interfacial catalysis by Aeromonas hydrophila lipase/acyltransferase in the highly processive scooting mode: Kinetic parameters, substrate specificities, and competitive inhibitors.
  38. M. H. Gelb, M. K. Jain and O. G. Berg (1994). FASEB J. 8: 916-924. Inhibition of phospholipase A2. (*)
  39. F. Bartoli, H.-K. Lin, F. Ghomashchi, M. G. Gelb, M. K. Jain, R. Apitz-Castro (1994). J. Biol. Chem. 269: 15625-15630. Tight binding inhibitors of the 85 kDa phospholipase A2 but not 14 kDa phospholipase A2 inhibit the release of free arachidonate in thrombin-stimulated human platelets.
  40. R. Wang, C. R. Dodia, M. K. Jain, A. B. Fisher (1994). Biochem. J. 304: 131-137. Purification and characterization of a calcium-independent acidic phospholipase A2 from rat lung.
  41. K. Seshadri, S. Vishveshwara, M. K. Jain (1994). Proc. Indian Acad. Sci. 106: 1177-1189. Binding of active site directed ligands to phospholipase A2: Implications on the molecular constraints and catalytic mechanism.
  42. Y. Li, B.-Z. Yu, H. Zhu, M. K. Jain, M. D. Tsai (1994). Biochemistry 33: 14714-14722. Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.
  43. X. Liu, H. Zhu, B. Huang, J. Rogers, B.-Z. Yu, A. Kumar, M. K. Jain, M. Sundaralingam, M.-D. Tsai (1995). Biochemistry, 34: 7322-7334. Phospholipase A2 engineering. Probing the structural and functional roles of N-terminus residues with site-directed mutagenesis, X-ray, and NMR.
  44. M. K. Jain, M. H. Gelb, J. Rogers, O. G. Berg (1995). Methods in Enzymology 249: 567-614. The kinetic basis of interfacial catalysis and activation of phospholipase A2. (*)
  45. M. K. Jain, B.-Z. Yu, J. M. Rogers, A. E. Smith, E.T.A. Boger, R. L. Ostrander, A. L. Rheingold (1995). Phytochemistry 39: 537-547. Specific competitive inhibitor of secreted phospholipase A2 from berries of Schscinus terebinthifolius.
  46. M. H. Gelb, M. K. Jain, A. M. Hanel, O. G. Berg (1995). Ann. Review of Biochem. 64: 653-688. Interfacial enzymology of glycerolipid hydrolases: Lessons from phospholipase A2. (*)
  47. T. Bayburt, B.-Z. Yu., I. Street, F. Ghomashchi, F. Laliberte, H. Perrier, Z. Wang, R. Homan, M. K. Jain, M. H. Gelb (1995). Analytical Biochemistry 232: 7-23. Continuous, vesicle-based fluorometric assays of 14-kDa and 85-kDa Phospholipase A2.
  48. Y. Cajal, O. G. Berg, M. K. Jain (1995). Biochem. Biophys. Res. Comm. 210: 746-752. Direct vesicle-vesicle exchange of phospholipid mediated by polymyxin B.
  49. M.-Q. Man, K. R. Feingold, M. K. Jain, P. M. Elias (1995). J. Lipid Research 36: 1925-1935. Extracellular processing of phospholipid is required for permeability barrier homeostasis.
  50. K. A. Kohler, M. K. Jain, D. A. Gabriel, H. Y. C. Chang, O. P. Malhotra (1995). J. Protein Chem. 14: 537-548. Intramolecular domain-domain interactions and intermolecular self-association in bovine prothrombin. A potentiometric and laser light-scattering study.
  51. M.-Q. Man, M. Jain, K. R. Feingold, P. M. Elias (1996). The Journal of Investigative Dermatology 106(1): 57-63. Secretory phospholipase A2 activity is required for permeability barrier homeostasis.
  52. Y. Cajal, J. Rogers, O. G. Berg, M. K. Jain (1996). Biochemistry 35: 299-308. Intermembrane molecular contacts by polymyxin B mediate exchange of phospholipid.
  53. Y. Cajal and M. K. Jain (1996). J. NIH Research, 8: 35-39. Membrane-membrane contacts: A "sorting" role for proteins?. (*)
  54. Y. Cajal, J. Ghanta, A. K. Surolia, E. Easwaran, M. K. Jain (1996). Biochemistry, 35: 5684-5695. Specificity for the transfer of phospholipid through polymyxin B mediated intermembrane molecular contacts.
  55. J. Rogers, B.-Z. Yu, S. V. Serves, G. M. Tsivgoulis, D. N. Sotiropoulos, P. V. Ioannou, M. K. Jain (1996). Biochemistry 35: 9375-9384. Kinetic basis for the substrate specificity during hydrolysis of phospholipid by secreted phospholipase A2.
  56. B. Huang, B.-Z. Yu, J. Rogers, I. J. Byeon, K. Sekar, X. Chen, M. Sundaralingam, M.-D. Tsai, M. K. Jain (1996). Biochemistry 35: 12164-12174. Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface.
  57. E. Ledezma, L. De Sousa, A. Jorquera, A. Lander, J. Sanchez, E. Rodriguez, M. K. Jain, R. Apitz-Castro (1996). Mycoses: 39: 393-395. Effectiveness of ajoene, an organosulfur derived from garlic, in the short-term therapy of Tinea pedis in humans.
  58. M. H. Gelb, M. K. Jain, O. G. Berg (1997). Principles of inhibition of phospholipase A2 and other interfacial enzymes. In Basic and Clinical Aspects of Inflammatory Diseases, (eds. W. Uhl, T. J. Nevalainnen and MW Buchler), Karger Verlag, Basel, 24: 123-129. (*)
  59. B.-Z Yu, F. Ghomashchi, Y. Cajal, R. R. Annand, O. G. Berg, M. H. Gelb, M. K. Jain (1997). Biochemistry, 36: 3870-3881. Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2.
  60. K. Sekar, B.-Z. Yu, J. Rogers, J. Lutton, X. Liu, X. Chen, M.-D. Tsai, M. K. Jain, M. Sundaralingam (1997). Biochemistry: 36: 3104-3114 (1997). Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.
  61. Y. Cajal, J. Boggs, M. K. Jain (1997). Biochemistry, 36: 2566-76. Salt-triggered intermembrane exchange of phospholipid and hemifusion by myelin basic protein.
  62. N. Y. Kim, U. D. Sohn, V. Mangannan, H. Rich, M. K. Jain, J. Behar, P. Biancani (1997). Gastroenterology, 112: 1548-1558. Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis.
  63. T. Kim, C. Sundaresh, S. I. Feinstein, C. Dodia, W. Skach, M. K. Jain, N. Nomura, T. Nagase, K. Ishikawa, A. Fisher (1997). J. Biol. Chem., 272: 2542-2550. Identification of a human cDNA clone for lysosomal-type Ca++-independent phospholipase A2 and properties of the expressed protein.
  64. Y. Cajal and M. K. Jain (1997). Biochemistry, 36: 3882-3893. Synergism between mellitin and phospholipase A2 from bee venom: Apparent activation by intervesicle exchange of phospholipid.
  65. B. Z. Yu, J. Rogers, G. Ranadive, S. Baker, D. C. Wilton, R. Apitz-Castro, and M. K. Jain (1997). Biochemistry, 36:12400-11. Gossypol modification of Ala-1 of secreted phospholipase A2: A probe for the kinetic effects of sulfated glycoconjugates.
  66. O. G. Berg, J. Rogers, B. Z. Yu, J. Yao, L. S. Romsted & M. K. Jain (1997). Biochemistry 36: 14512-14530. Thermodynamic and kinetic basis for interfacial activation: Resolution of binding and allosteric effects on pancreatic phospholipase A2 at zwitterionic interfaces.
  67. K. Sekar, S. Eswaramoorthy, M. K. Jain & M. Sundaralingam (1997). Biochemistry 36:14186-14191. Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor (MJ33) 1-hexadecyl-3-trifluoro ethyl-sn-glycero-2-phosphomethanol.
  68. O. G. Berg, Y. Cajal, G. L. Butterfoss, R. L. Grey, M. A. Alsina, B. Z. Yu, and M. K. Jain (1998). Biochemistry 37: 6615-6627. Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid.
  69. T. S. Kim, Dodia, C., X. Chen, B. B. Hennigan, M. K. Jain, S. I. Sheldon, and A. B. Fisher (1998). Amer. J. Physiology: Lung Cellular and Molecular Physiology, 274, L750-761. Cloning and expression of rat lung acidic Ca++-independent phospholipase A2 and its organ distribution.
  70. F. Ghomashchi, Y. Lin, M. S. Hixon, B. Z. Yu, R. Annand, M. K. Jain, and M. H. Gelb (1998). Biochemistry 37: 6697-6710. Interfacial recognition by bee venom phospholipase A2: Insights into non-electrostatic molecular determinants by charge reversal mutagenesis.
  71. Y. Lin, F. Ghomashchi, R. Nielson, Y. Snitko, B. Z. Yu, S. K. Han, W. Cho, D. C. Wilton, M. K. Jain, B. H. Robinson, and M. H. Gelb (1998). Biochemical Soc. Trans. 26: 341-345. Binding of bee venom and human group IIa phospholipase A2 to membranes: A minor role for electrostatics.
  72. J. Rogers, B. Z. Yu, M. D. Tsai, O. G. Berg, and M. K. Jain (1998). Biochemistry 37: 9549-9556. Cationic residues 53 and 56 control the anion-induced interfacial k*cat-activation of pancreatic phospholipase A2.
  73. J. T. Oh, T. J. Van Dyk, Y. Cajal, P. Dhurjati, M. Sasser and M. K. Jain (1998). Biochemical Biophysical Research Communication 246: 619-623. Osmotic stress in viable Escherichia coli as the basis for the antibiotic response by polymyxin B.
  74. B. Z. Yu, J. Rogers, G. Nicol, K. H. Theopold, K. Seshadri, S. Vishweshwara, and M. K. Jain (1998). Biochemistry 37: 12576-12587. Catalytic significance of the specificity of divalent cations as KS* and k*cat cofactor for secreted phospholipase A2.
  75. Y. Cajal, C. Dodia, A. B. Fisher, and M. K. Jain (1998). Biochemistry 37: 12178-12188. Calcium triggered selective intermembrane exchange of phospholipid by the lung surfactant protein SP-A.
  76. M. K. Jain (1998). Quart. Rev. Biol. 73: 329-332. Greed and Grab: Many are called yet few are chosen.
  77. J. T. Oh, T. K. Van Dyk, Y. Cajal, M. Sasser, and M. K. Jain (1998).  Biochim. Biophys. Acta, 1415, 235-245.  Cecropin induces selective hyperosmotic stress transcriptional response in Escherichia coli.
  78. B. Z. Yu, J. Rogers, M. D. Tsai, C. Pidgeon, and M. K. Jain (1999).  Biochemistry, 38: 4875-4884.  Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis and activation.
  79. M. K. Jain (1999) Quarterly Rev. Biol. 74:  47-49. Acertaining nature's veracity.
  80. R. Homan and M. K. Jain (1999). In Intestinal Lipid Metabolism, eds. C. M. Mansbach, P. Tso, and A. Kuksis, Plenum, N. Y., in press.  Biology, pathology and interfacial enzymology of pancreatic phospholipase A2.
  81. M. K. Jain (1999).  Jinamanjari 19:13-17.  Asti and syad in Jaina Thought.
  82. A. Z. fernandez, M. K. Jain, R. Apitz-Castro (1999). Encyclopedia of Life Sciences (Article #1392). Eicosanoid Biosynthesis.
  83. A. B. Fisher and M. K. Jain (1999). Encyclopedia of Life Sciences. (Article #1394)  Phospholipases: Degradation of membrane phospholipids.
  84. Jain, M. K. and M. Bruch (1999). In  Membrane Structure in Disease and Drug Therapy, ed. G. Zimmer. in press, Marcel Dekker, New York.  The antimicrobial mechanism for polymyxins.
  85. Cajal, Y., and M. K. Jain (1999). In  Membrane Structure in Disease and Drug Therapy, ed. G. Zimmer. in press, Marcel Dekker, New York. Synergistic action of mellitin on phospholipase A2 catalysis.
  86. Yu, B. Z., O. G. Berg, and M. K. Jain (1999). Biochemistry, in review.  Hydrolysis of monodisperse substrate by phospholipase A2 occurs at surfaces.
  87. J. T. Oh, Y. Cajal, E. M. Skowronska, S. Belkin, J. Chen, T. K. Van Dyk, M. Sasser, and M. K. Jain (2000). Biochim. Biophys. Acta. 1463: 43-54.  Cationic peptide antimicrobials induce transcription of micF and osmY in  Escherichia coli.
  88. A. Liechty, J. Chen, and M. K. Jain (2000). Biochim. Biophys. Acta.  1463: 55-64.  Origin of antibacterial stasis by polymyxin B in Escherichia coli.
  89. Jain, M. K., and M. Bruch  (2000). In  Membrane Structure in Disease and Drug Therapy, ed. G. Zimmer, Marcel Dekker, New York, pp. 63-76.  Polymyxins: Prototypes for a new class of antibiotics.
  90. Cajal, Y., and M. K. Jain (2000). In  Membrane Structure in Disease and Drug Therapy, ed. G. Zimmer, Marcel Dekker, New York, pp. 45-62. Bee venom toxicity: Synergistic action of mellitin on interfacial hydrolysis by phospholipase A2.
  91. A. Z. Fernandez, M. K. Jain, R. Apitz-Castro (2000). Encyclopedia of Life Sciences (Article #1392). Eicosanoid Biosynthesis.
  92. A. B. Fisher and M. K. Jain (2000). Encyclopedia of Life Sciences. (Article #1394)  Phospholipases: Degradation of membrane phospholipids.
  93. R. Homan and M. K. Jain (2000). In Intestinal Lipid Metabolism, eds. C. M. Mansbach, P. Tso, and A. Kuksis, Kluwer Academic Press, Plenum Publ., N. Y.,  81-104.  Biology, pathology and interfacial enzymology of pancreatic phospholipase A2.
  94. B. Z. Yu, M. J. W. Janssen,  H. M. Verheij, and M. K. Jain (2000). Biochemistry 39, 5702-5711.  Control of the chemical step by leucine-31 of pancreatic phospholipase A2.
  95. M. H. Gelb, J. H., Min,  M. K. Jain (2000). Biochim. Biophys. Acta, 1488, 20-27. Do membrane bound enzymes access their substrates from the membrane or aqueous phase: Interfacial versus non-interfacial enzymes.
  96. J. W. Chen, C. Dodia, S. I. Feinstein, M. K. Jain, A. B. Fisher (2000), J. Biol. Chem. 275, 28421-28427. 1-Cys peroxiredoxin: a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
  97. Yu, B. Z., Poi, M. J., Ramagopal, U. A., Jain, R., Ramakumar, S., Berg, O. G., Tsai, M. D., Sekar, K., and Jain, M. K. (2000). Biochemistry 39: 12312-23. Structural basis of the anionic interface preference and k*cat-activation of pancreatic phospholipase A2.
  98.   Pan, Y. H., Epstein, T. M., Jain, M. K., Bahnson, B. J. (2001).  Biochemistry 40: 609-617.  Five coplanar anion binding sites on one face of phospholipase A2: Relationship to interface binding.
  99. Berg, O. G., Tsai, M. D.,  Gelb, M. H.,  Jain, M. K. (2001). Chemical Reviews, 101, 2613-2653.  Interfacial Enzymology: The secreted phospholipase A2-paradigm.
  100. Epstein, T. M.; Yu, B.-Z.; Pan, Y. H.; Tutton, S. P.; Maliwal, B. P.; Jain, M. K.; Bahnson, B. J. (2001). Biochemistry 40, 11411-11422.  The basis for k*cat-impairment in phospholipase A2 from the anion-assisted dimer structure.
  101. Berg, O. G., and Jain, M. K. (2002): Interfacial Enzyme Kinetics.  pp.302. John Wiley & Sons.
  102. Jain, M. K. (2001). Book Review of Human Natures: Genes, Cultures, and the Human Prospect by Paul R. Ehrlich. Quarterly Review of Biology 76: 345-346.
  103. Jain, M. K. (2001). Book Review of Ramachandran by R. Sarma. Quarterly Review of Biology 76: 59-60.
  104. Yu, B.-Z., Zakim, D., Jain, M. K. (2002). Biochim. Biophys. Acta 1583, 121-131. Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles.
  105. Pan, Y. H., Yu. B.-Z., Singer, A. G., Ghomashchi, F., Lambeau, G., Gelb, M. H., Jain, M. K., Bahnson, B. J. (2002). J. Biol. Chem. 277, 20986-93. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial binding surface targets zwitterionic membranes.
  106. Pan, Y. H., Yu, B. Z., Berg, O. G., Jain, M. K., Bahnson, B. J. (2002). Biochemistry 41, 14790-8000. Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: Equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive.
  107. Jain, M. K. (2002). Being to Becoming (3 Volumes, 950 pages). Hira Publications, Washington DC. ISBN# 0-9721569-0-9. E-book on http://www.hira-pub.org/
  108. Jain, M. K. (2003). Representation of Order with Room for Doubt, The Quarterly Review of Biology 78: 203-207. A Review of A New Kind of Science by Stephen Wolfram.
  109. Yu, B. Z., Apitz-Castro, R., Tsai, M. D., and Jain, M. K. (2003) Biochemistry 42, 6293-6301. Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.
  110. D. N. Georgieva, W. Rypniewski, M. Perbrandt, Jain, M.K., Genov, N., and Betzel, C. (2003) Biochim. Biophys. Acta 1650, 1-3 (2003). Crystallization and preliminary x-ray diffrection studie of a toxic phospholipase A2 from the venom of Vipera ammodytes meridionalis complexed to a synthetic inhibitor.
  111. Otto G. Berg*, Bao-Zhu Yu, Rafael J. Apitz-Castro and Mahendra K. Jain* (2004). Biochemistry, 43, 2080-2090. PI-Specific Phospholipase C forms Different Complexes with Monodisperse and Micellar Phosphatidylcholine.
  112. Yolanda Cajal, Otto G. Berg, and Mahendra Kumar Jain (2004). Biochemistry, 43, 9256-64. Origins of Delays in Monolayer Kinetics: Phospholipase A2 Paradigm.
  113. Otto G. Berg, B-Z. Yu, C. Chang, Karl A. Koehler, and Mahendra K. Jain (2004). Biochemistry, 43, 7999-8013. Cooperative binding of monodisperse anionic amphiphiles to the i-face of phospholipase A2.
  114. Mahendra Kumar Jain (2204). Room for Doubt, Hira Publications, Washington DC. E-book on http://www.hira-pub.org/.


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