Delaware Chapter, ASA
Dinner Meeting: February 2008
|| Our meetings are located at the Blue and Gold Club Tavern
on the University of Delaware campus.
||The schedule of meetings for Spring 2008 is set. See our Vice
summarizing the meetings and offering words of praise and
||Also see a very nice summary of our Fall
2007 meetings along with photos of our speakers.
Professor Hongzhe Li|
Department of Biostatistics and Epidemiology
University of Pennsylvania
School of Medicine
Statistical Methods for Network-Based Analysis of Genomic Data
A central problem in genomic research is the identification of
genes and pathways that are involved in diseases or perturbed
during a biological process. Many methods have been developed for
identifying genes in regression frameworks. The genes identified
are often linked to known biological pathways through gene set
enrichment analysis in order to identify the pathways involved.
However, most of the procedures of identifying the biologically
relevant genes do not utilize the known pathway information. In
this talk, I present hidden Markov random field (HMRF)-based
methods for identifying genes and subnetworks that are activated or
perturbed by diseases or biological processes, where the latent
gene differential expression states are modeled by a discrete
Markov random field. Simulation studies indicated that the methods
are effective in identifying genes and subnetworks that are related
to disease and have higher sensitivity and lower false discovery
rates than the commonly used procedures that do not use the pathway
structure information. I will demonstrate these methods by
analyzing a breast cancer gene expression dataset to identify the
modules related to cancer metastasis and a systemic immune response
time course gene expression dataset to identify the subnetworks
involved in human immune response to endotoxin.
||Thursday, February 21, 2008|
||Social hour -- 6:00 pm|
Dinner -- 6:30 pm
Speaker -- 7:15 pm
||Blue and Gold Club Tavern|
University of Delaware
|| Buffet or order from menu -- depending on attendance
|| $25 for members, $15 for students|
Or pay for your meal from the menu + $5.00.
|Bruce Stanley by Wednesday,
February 20, 2008.|
Please note: Be sure to RSVP by this date.
Return to Delaware Chapter ASA home page.